MabSelect Xtra, with extra high dynamic binding capacity, is a protein A resin developed to meet the demands of increasing levels of expression in monoclonal antibody feedstocks.
Higher dynamic binding capacity than currently available Protein A chromatography resins.
Improved process economics through reduced raw materials costs and/or reduced number of cycles.
High purity capture due to high ligand selectivity and matrix hydrophilicity.
Slightly lower pressure/flow properties compared to MabSelect SuRe and MabSelect.
Resin fulfills industrial demands for security of supply, robust performance, and regulatory support.
Increased porosity
MabSelect Xtra has the same recombinant Protein A ligand as MabSelect but is based on a high-flow agarose base matrix with increased porosity and a slightly decreased particle size compared to MabSelect. This results in higher capacity—MabSelect Xtra has about 30% higher dynamic binding capacity for IgG than currently available Protein A chromatography resins.
In addition, MabSelect Xtra has a higher capacity for many Fc-fusion proteins.
Lower costs
Compared with he other protein A resins, MabSelect Xtra resin provides a lower overall production cost due to the possibility of processing concentrated feedstocks in fewer batches.
Prepacked columns and other formats
MabSelect Xtra is available in the following formats:
Process development scale – prepacked
PreDictor MabSelect Xtra filter plates – 96-well plates for high-throughput screening or process development.
PreDictor RoboColumn MabSelect Xtra – minitiaturized column format for high throughput process development
HiScreen MabSelect Xtra columns – optimized for method and process development.
Lab/research scale – prepacked for manual purification
HiTrap MabSelect Xtra columns – for easy use with a syringe, peristaltic pump, or chromatography system.
Lab/research scale – prepacked for automated purification and analysis
HiTrap MabSelect Xtra columns – for easy use with a syringe, peristaltic pump, or chromatography system.
