LYS6K2, S6K inhibitor

Product Details

Formal Name: 4-(4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazol-2-yl)piperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine

Molecular Formula: C₂₁H₁₉F₄N₇

Formula Weight: 445.42

CAS Number: 1082949-68-5

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 1 mg/ml) or in DMF (up to 3 mg/ml).

Storage: RT

Stability: ≥ 2 years.

Applications

S6K inhibitor

Functions

A selective inhibitor of the p70 ribosomal S6 kinase (S6K). Blocks the phosphorylation of S6 at concentrations as low as 0.1-0.3 μM with no activity at GSK3β and Erk1/2 at 10 μM. Useful tool to dissect insulin receptor signaling pathways and was employed to show that the action of mTORC1 on SREB P-1c expression is not mediated by S6K.  Cell permeable.

Application Procedures

First dissolved in DMSO (up to 1 mg/ml) or in DMF (up to 3 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)