Lumos 96 Optical Stimulation System

Use Lumos to control cell biology

Control cellular biology on a high-throughput scale

Light-mediated control of biochemical, genetic, and cellular functions is an emerging tool in many research fields:

• >>  Control intracellular signaling pathways
• >>  Direct gene expression with light
• >>  Edit genes with light-induced CRISPR/Cas9
• >>  Influence growth and regeneration

Lumos ECbase is compatible with standard lab warming plates and has a built-in gas delivery port to enable a controlled CO₂ environment during Lumos Optical stimulation.

Use Lumos to control cell activity

Control cell activity with light

Optogenetics techniques use genetic targeting to express light-sensitive ion channels called opsins (e.g. ChR2) in targeted cell populations. Upon stimulation by a specific wavelength of light, these opsins can be activated to shift the cell membrane potential. Light of specific wavelengths can thus be used to activate or silence cell activity in targeted cell populations.

Advantages of optogenetic-mediated control of cell activity include:

• >>  Artifact-free stimulation
• >>  Precise control of cell activity
• >>  Reduced experimental variability
• >>  Cell specific control

Axis Navigator - Stimulation Studio

The Neural Applications and Cardiac Applications modules support Lumos optical stimulation with Stimulation Studio in AxIS Navigator™. Enabling fast, flexible set-up, Stimulation Studio provides intuitive, visual stimulation programming in an easily accessible plate map format. Here, each of the LEDs can be independently controlled for intensity (1-100% max power) and duration (down to 100 microseconds), and stimulation protocols can be designed quickly and easily with a drag-and-drop interface.