Lipoic acid (DL, α), Endogenous antioxidant and cofactor

Product Details

Formal Name: 1,2-dithiolane-3-pentanoic acid, racemic

Alternate Names: Thioctic acid

Molecular Formula: C₈H₁₄O₂S₂

Formula Weight: 206.30

CAS Number: 1077-28-7

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to at least 30 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Endogenous antioxidant and cofactor

Functions

alpha-Lipoic acid is an endogenous antioxidant. Treatment with alpha-lipoic acid increased hepatic nuclear Nrf2 levels, induced Nrf2-mediated gene transcription, and reversed age-related decline in hepatic glutathione levels in a rat model. It is an essential cofactor required for catalysis by multiple mitochondrial enzymes including pyruvate dehydrogenase, α-ketoglutarate dehydrogenase and branched-chain ketoacid dehydrogenase among others. It has shown efficacy as a treatment in diabetic neuropathy.

Application Procedures

First dissolved in DMSO (up to at least 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored under an inert atmosphere at -20°C for up to 1 month.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)