Solubility: Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
Storage: RT
Stability: ≥ 1 year.
Applications
Casein kinase 1d inhibitor
Functions
Potent and selective inhibitor of casein kinase (CK) 1δ., IC50s=0.29, 1.3 and 2.5 μM for δ, ε and α isoforms respectively with no inhibition of CK2. Inhibits CK1δ-mediated phosphorylation and degradation of PER1 protein and lengthens circadian period in U2OS cells.
Application Procedures
First dissolved in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
