Lenalidomide, TNFa inhibitor

Product Details

Formal Name: (R,S)-3-(4-Amino-1-oxo-3H-isoindol-2-yl)piperidine-2,6-dione

Alternate Names: CC-5013

Molecular Formula: C₁₃H₁₃N₃O₃

Formula Weight: 259.26

CAS Number: 191732-72-6

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 30 mg/ml).

Storage: RT

Stability: ≥ 1 year.

Applications

TNFa inhibitor

Functions

Thalidomide analog which, like thalidomide, binds to cereblon which is the substrate recognition component of a cullin-dependent ubiquitin ligase and inhibits its autoubiquitination activity.  Induces degradation of T-cell repressors Ikaros (IKZF1) and Aiolos (IKZF3) leading to T cell activation.  Selective inhibition of IKZF1 and IKZF3 in multiple myeloma cells results in cell death. Cell permeable. Caution: Teratogenic

Application Procedures

First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)