Lamivudine, Reverse transcriptase inhibitor

Product Details

Formal Name: 4-Amino-1-[(2R,5S)-2-(hydroxymethyl)1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone

Alternate Names: (-)-BCH-189; 3TC

Molecular Formula: C₈H₁₁N₃O₃S

Formula Weight: 229.30

CAS Number: 134678-17-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 30 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Reverse transcriptase inhibitor

Functions

A nucleoside analog reverse transcriptase inhibitor. A potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2).  Displays anti-inflammatory effects, including reduction of inflammasome-related proteins P2X7 and NLRP3, in retinal microvascular endothelial cells treated with high glucose and LPS as well as in streptozotocin diabetic mice. Disrupts repeat element life cycle in colorectal cancer.

Application Procedures

First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)