L-Cycloserine, Sphingolipid biosynthesis inhibitor

Product Details

Formal Name: (S)-4-Amino-3-isoxazolidinone

Alternate Names: L-(-)-Cycloserine; S-Cycloserine

Molecular Formula: C₃H₆N₂O₂

Formula Weight: 102.1

CAS Number: 339-72-0

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to 20 mg/ml, warm) or in Water (up to 25 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

Sphingolipid biosynthesis inhibitor

Functions

Down-regulates sphingolipid biosynthesis via inhibition of serine palmitoyltransferase (3-ketodihydrosphingosine synthetase). The L isomer was shown to be 100-fold more potent than the D isomer at inhibition of the brain microsomal enzyme. It is a useful pharmacological agent for lowering sphingolipid levels in cells as well as in animal models. Inhibition of de novo ceramide biosynthesis with L-cycloserine positively affected the senescent phenotype, restoring neuronal signaling and reducing mitochondrial dysfunction in a cortical neuronal model of senescence.

Application Procedures

First dissolved in DMSO (20 mg/ml) or in Water (25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or water may be stored at -20°C for up to 1 month.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)