Jervine, Hedgehog inhibitor

Product Details

Formal Name: (3β,23β)-17,23-Epoxy-3-hydroxyveratraman-11-one

Alternate Names: 11-Ketocyclopamine

Molecular Formula: C₂₇H₃₉NO₃

Formula Weight: 425.60

CAS Number: 469-59-0

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 5 mg/ml), in DMF (up to 6 mg/ml), or in Ethanol (up to 20 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

Hedgehog inhibitor

Functions

Inhibitor of Hedgehog signaling (IC50 = 0.5-0.7 µM). Binds directly to Smoothened (Smo). Inhibits the response of target tissues to Sonic hedgehog signaling.  Induces COX-2 overexpression in human erythroleukemia cells.

Application Procedures

First dissolved in DMSO (up to 5 mg/ml), in DMF (up to 6 mg/ml), or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO, ethanol or DMF may be stored at -20° for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)