Irinotecan HCl, Topoisomerase I inhibitor

Product Details

Formal Name: (S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3’,4’:6,7]-indolizino[1,2-b]quinolin-9-yl-[1,4’-bipiperidine]-1’-carboxylate hydrochloride

Molecular Formula: C₃₃H₃₈N₄O₆ ∙ HCl ∙ 3H₂0

Formula Weight: 586.69 ∙ 36.46 ∙ 54.05

CAS Number: 100286-90-6

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 50 mg/ml), in Water (up to 4 mg/ml) or in Ethanol (up to 4 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

Topoisomerase I inhibitor

Functions

Irinotecan is a semi-synthetic derivative of camptothecin that is an FDA approved anticancer drug.  It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38), a potent inhibitor of DNA topoisomerase I. Although irinotecan is also a topoisomerase inhibitor, SN-38 is approximately 1000 times as potent in purified enzyme studies. In vitro cytotoxicity assays show much greater variability in potency between the two (2-2000 fold).

Application Procedures

First dissolved in DMSO (up to 50 mg/ml), in Water (up to 4 mg/ml) or in Ethanol (up to 4 mg/ml), then diluted to aqueous buffer. Solutions in DMSO, ethanol or distilled water may be stored at -20° for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)