Ipatasertib, Pan-Akt inhibitor

Product Details

Formal Name: (2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-yla,ino)propan-1-one

Alternate Names: GDC-0068; RG7440

Molecular Formula: C24H32ClN5O42

Formula Weight: 458.00

CAS Number: 1001264-89-6

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml) or ethanol (up to 20 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Pan-Akt inhibitor

Functions

Ipatasertib is a selective (against a panel of 230 kinases) and potent pan-Akt inhibitor (IC50s: Akt1 = 5 nM, Akt2 = 18 nM, Akt3 = 8 nM).1 It displayed efficacy in xenograft models of prostate, breast, ovarian, colorectal, non-small cell lung, glioblastoma, and melanoma cancers.2 In clinical trials.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml) or ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)