IPA-3 is a selective allosteric inhibitor of Group 1 p21-activated kinase (PAK1 IC50 = 2.5 µM) via covalent binding to the PAK1 regulatory domain preventing binding to the upstream activator Cdc42. IPA-3 has been shown to induce cell death in human leukemic cell lines, significantly inhibit TGFβ1-induced prostate cell epithelial to mesenchymal transition and inhibits the growth of liver cancer cells.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
