Indoximod, IDO modulator / tryptophan mimetic

Product Details

Formal Name: 1-Methyl-D-tryptophan

Molecular Formula: C₁₂H₁₄N₂O₂

Formula Weight: 218.25

CAS Number: 110117-83-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (greater than 25 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

IDO modulator / tryptophan mimetic

Functions

Indoximod is a modulator of indoleamine 2,3-dioxygenase (IDO) activity. IDO can be used by tumors to avoid elimination by the host immune response, thus inhibition of IDO is an interesting cancer therapeutic option.  Indoximod is not a direct inhibitor of IDO, but instead targets the IDO gene leading to downstream effects.  IDO-mediated catabolism of tryptophan inhibits the immunoregulatory kinases mTOR and PKC5. This is relieved by Indoximod acting as a potent tryptophan mimetic restoring mTOR and PKC signaling.

Application Procedures

First dissolved in DMSO (greater than 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 month.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)