icFSP1, Ferroptosis suppressor protein (FSP1) inhibitor

Product Details

Formal Name: 3,4,5-Trimethoxy-N-[4-(2-methyl-4-oxo-3(4H)-quinazolinyl)phenyl]-benzeneacetamide

Molecular Formula: C₂₆H₂₅N₃O₅

Formula Weight: 459.5

CAS Number: 1115910-36-5

Purity: >96%

Formulation: Powder

Solubility: Soluble in DMSO (40 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Ferroptosis suppressor protein (FSP1) inhibitor

Functions

Ferroptosis suppressor protein-1 (FSP1), along with ubiquinone and NAD(P)H/H⁺, has been identified as a second ferroptosis-suppressing system which prevents lipid peroxidation independently of the cysteine-glutathione-glutathione peroxidase 4 (GPX4) axis. icFSP1 was discovered in a screen to identify inhibitors of FSP1. However it does not competitively inhibit FSP1 enzyme activity but triggers subcellular relocalization of FSP1 (at 2.5 µM) from the membrane and FSP1 condensation before ferroptosis induction.  icFSP1-induced FSP1 condensates show droplet-like properties consistent with phase separation. icFSP1-impairs tumor growth and induces FSP1 condensates in tumors in vivo.

Application Procedures

First dissolved in DMSO (40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)