Hydroxyurea, Anticancer agent

Product Details

Formal Name: N-hydroxyurea

Alternate Names: Hydroxycarbamide

Molecular Formula: CH₄N₂O₂

Formula Weight: 76.10

CAS Number: 127-07-1

Purity: >98%

Formulation: powder

Solubility: Soluble in Water (up to 50 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Anticancer agent

Functions

Readily oxidized in vivo to free radical forms, which destroy the stable tyrosyl free radical of the metalloenzyme ribonucleotide reductase, suppressing deoxyribonucleotide production and blocking DNA synthesis and repair. Reduces cell proliferation, and causes S-phase arrest and death. Induces p53-dependent NF-κB target gene expression in U2OS cells expressing HA-RelA. Stimulates fetal hemoglobin production in vitro and in vivo. Allows for S phase enrichment of CHO cells with maintenance of viability for enhanced site-specific genome engineering. Anticancer and antiviral agent.

Application Procedures

First dissolved in Water (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in water may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)