Homoharringtonine, Protein synthesis inhibitor

Product Details

Formal Name: Cephalotaxine 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate

Alternate Names: HHT; NSC 141633; Omacetaxine mepesuccinate

Molecular Formula: C₂₉H₃₉NO₉

Formula Weight: 545.60

CAS Number: 26833-87-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 75 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Protein synthesis inhibitor

Functions

Homoharringtonine is a plant alkaloid, originally isolated from the Hainan plum yew, that binds to the large ribosomal subunit A-site, competing with aminoacyl-tRNA amino acid side chains, thereby inhibiting the initial elongation step of protein synthesis. It also binds to transcription factors NKRF (NF-κB repressing factor) and SP1, down-regulating the Myc pathway. Dramatically decreases global DNA 5-hydroxymethylcytosine levels via the SP1/TET1 axis. Induces apoptosis in tyrosine kinase inhibitor-resistant NSCLC cells, and is a clinically useful agent for CML and AML.

Application Procedures

First dissolved in DMSO (up to 75 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)