GW788388, TGFβ receptor inhibitor

Product Details

Formal Name: 4-(4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide

Molecular Formula: C₂₅H₂₃N₅O₂

Formula Weight: 425.50

CAS Number: 452342-67-5

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (40 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

TGFβ receptor inhibitor

Functions

Potent inhibitor of TGF-β receptor kinases ALK4, ALK5 (IC50=18 nM), ALK7, and TGFβRII, but not BMP type II receptor kinase. Blocks TGF-β-mediated signaling, including collagen type I and VEGF, in turn reducing fibrosis and angiogenesis in various mouse models. GW788388 attenuates TGF-β-induced epithelial to mesenchymal transition (EMT) in human peritoneal mesothelial cells.

Application Procedures

First dissolved in DMSO (40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)