GW1100, GPR40 antagonist

Product Details

Formal Name: 1-(4-Ethoxycarbonylphenyl-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone

Molecular Formula: C₂₇H₂₅FN₄O₄S

Formula Weight: 520.59

CAS Number: 306974-70-9

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 2 mg/ml) or in DMF (up to 5 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

GPR40 antagonist

Functions

Selective antagonist of GPR40. GW1100 inhibits GRP40-mediated Ca2+ increases stimulated GW9508 or linoleic acid (pIC50 = 5.99 for either agonist). The effects of GPR40 activation on insulin secretion in cells are also blocked by the addition of GW1100. GW1100 does not influence calcium mobilization mediated by GPR120.

Application Procedures

First dissolved in DMSO (up to 2 mg/ml) or in DMF (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or DMF may be stored at -20° for up to 3 months. Dilutions into aqueous media are not stable and should be used within one working day.

Research use only.

Documents

• Datasheet (PDF)