Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Storage: RT
Stability: ≥ 1 year.
Applications
GPR40 agonist
Functions
Selective agonist at the free fatty acid receptor, FFA1/4, (GPR40 and GPR120). Displays anti-allodynic and anti-hyperalgesic effects in mouse inflammatory and neuropathic pain models. Inhibits LPA-induced proliferation of DU145 and PC-3 cells. Decreases hepatic lipid accumulation in a high fat diet steatosis mouse model. Promotes brown adipose tissue thermogenesis.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
