Gue-1654, OXE-R antagonist

Product Details

Formal Name: N-[7-(Methylthio)benzo[1,2-d:4,3-d’]bisthiazol-2-yl]-α-phenylbenzeneacetamide

Molecular Formula: C₂₃H₁₇N₃OS₃

Formula Weight: 447.59

CAS Number: 397290-30-1

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (40 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

OXE-R antagonist

Functions

Gue1654 is a biased antagonist for the oxoeicosanoid receptor 1 (OXE-R, GPR170)1, the receptor for 5-Oxo-ETE, a proinflammatory eicosanoid. It selectively inhibits Gβγ but not Gαi signaling upon activation of the Gαi-βγ heterotrimer by OXE-R. Gue1654 alleviated coronary artery ligation-induced ischemic myocardial injury in a mouse model.

Application Procedures

First dissolved in DMSO (40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)