GSK2636771, Selective PI3Kß inhibitor

Product Details

Formal Name: 2-Methyl-1-(2-methyl-3-(trifluoromethyl)benzyl)-6-morpholino-1H-benzo[d]imidazole-4-carboxylic acid

Molecular Formula: C₂₂H₂₂F₃N₃O₃

Formula Weight: 433.4

CAS Number: 1372540-25-4

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to 20 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Selective PI3Kß inhibitor

Functions

Potent, selective (>1000-fold over α, 10-fold over δ, and >2000-fold over γ), and orally bioavailable inhibitor of PI3Kß (IC₅₀ = 5.2 nM). Active in vitro against multiple types of PTEN-deficient cancer cells. GSK2636771 potently blocked migration and invasion of DU145 prostate cancer cells. GSK2636771 has also been identified as a GPR39 agonist.

Application Procedures

First dissolved in DMSO (20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)