Formal Name: Fermentation product from Penicillium sp.
Molecular Formula: C17H17ClO6
Formula Weight: 352.77
CAS Number: 126-07-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 40 mg/ml), in DMF (up to 50 mg/ml), or in Ethanol (up to 5 mg/ml).
Storage: RT
Stability: ≥ 1 year.
Applications
Centrosomal clustering inhibitor
Functions
Antifungal antimitotic agent. Induces apoptosis of human germ cell tumor cells via disruption of connexin 43/tubulin association concomitant with enhanced translocation of connexin 43 from the cytoplasm to the nucleus. Inhibits the growth of adrenocortical cancer cells in vitro. Inhibits centrosome clustering, induces spindle multipolarity, mitotic arrest and cell death in multiple tumor cell lines but not in diploid fibroblasts and keratinocytes with normal centrosome content.
Application Procedures
First dissolved in DMSO (up to 40 mg/ml), in DMF (up to 50 mg/ml), or in Ethanol (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 3 months.
