Ginkgolide B, PAF antagonist

Product Details

Formal Name: Natural product isolated from Ginko biloba

Alternate Names: BN 52021

Molecular Formula: C₂₀H₂₄O₁₀

Formula Weight: 424.41

CAS Number: 15291-77-7

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

 

Applications

PAF antagonist

 

Functions

Platelet-activating factor (PAF) receptor antagonist (Ki = 1.3 μM). Inhibits neutrophil degranulation and superoxide production in vitro. Inhibits PAF-induced bronchoconstriction in a guinea pig model. Displays neuroprotective effects in various models. Protects against focal cerebral ischemia via inhibition of the mitochondrial apoptotic pathway.

 

Application Procedures

First dissolved in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or Ethanol may be stored at -20°C for up to 3 months.

 

Research use only.

Documents

• Datasheet (PDF)