Gabapentin lactam, Neuroprotective agent

Product Details

Formal Name: 4,4-Pentamethylene-2-pyrrolidone

Alternate Names: GBP-L

Molecular Formula: C₉H₁₅NO

Formula Weight: 153.22

CAS Number: 64744-50-9

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 40 mg/ml)

Storage: RT

Stability: ≥ 1 year.

Applications

Neuroprotective agent

Functions

Reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease. Displays neurotrophic effects, enhancing the formation of dendritic filopodia and inducing a network of F-actin-containing neurites in cultured hippocampal neurons. Promotes the survival of cultured central nervous system neurons possibly by opening mitochondrial KATP channels. Displays neuroprotective effects in a rat model of acute retinal ischemia.

Application Procedures

First dissolved in DMSO (up to 40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)