Fludarabine, DNA synthesis inhibitor

Product Details

Formal Name: 9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine

Alternate Names: F-ara-A; NSC118218

Molecular Formula: C₁₀H₁₂FN₅O₄

Formula Weight: 285.2

CAS Number: 21679-14-1

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to 30 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

DNA synthesis inhibitor

Functions

A synthetic adenosine analog that inhibits DNA biosynthesis and is a clinically useful antineoplastic agent. In cells fludarabine accumulates as its 5’-triphosphate (F-ara-ATP) for which the rate-limiting step in formation is the conversion of fludarabine to its monophosphate. F-ara-ATP has multiple mechanisms of action including inhibition of ribonucleotide reductase, DNA polymerase, ligase and primase. A frequently used agent in myeloablative conditioning regimens for allogeneic hematopoietic cell transplantation. Immunosuppressive effects are mediated via inhibition of TNFα-stimulated production of IL-2 and IFN-γ through inactivation of NFκB. Antagonist at adenosine A1 receptors.

Application Procedures

First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)