FLI-06, Notch pathway inhibitor

Product Details

Formal Name: Cyclohexyl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate

Molecular Formula: C₂₅H₃₀N₂O₅

Formula Weight: 438.52

CAS Number: 313967-18-9

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

Notch pathway inhibitor

Functions

FLI-06 was discovered in a screen designed to monitor the trafficking and processing of a ligand-independent Notch-enhanced GFP reporter. It disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and inhibited general secretion at a step before exit from the ER which was accompanied by a tubule-to-sheet morphological transition of the ER and is thus a novel agent acting at an early stage in secretory traffic (EC50=2.3 μM). Abolishes MFAP5-dependent transcriptional programs which are upregulated in intrahepatic cholangiocarcinoma. Suppresses proliferation and induces apoptosis in esophogeal squamous cell carcinoma cells.

Application Procedures

First dissolved in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)