Flavopiridol HCl (Alvocidib), CDK inhibitor

Product Details

Formal Name: 2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one, hydrochloride

Alternate Names: L 86-8275; Alvocidib; NSC-649890

Molecular Formula: C₂₁H₂₀ClNO₅  HCl

Formula Weight: 438.30

CAS Number: 131740-09-5

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 40 mg/ml) or in Water (up to 40 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

CDK inhibitor

Functions

Cyclin-dependent kinase (CDK) inhibitor that causes cell cycle arrest at G1 and G2 phase. Potentiates (100-200 nM) PMA-induced apoptosis in HL-60 and U937 cells. Potentiates the effects of topoisomerase I inhibitors by suppressing Rad51 expression in a p53-dependent manner. Displays potent antiviral activity against HIV-1 and HSV-1 in vitro.

Application Procedures

First dissolved in DMSO (up to 40 mg/ml) or in Water (up to 40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.

Research use only.

Documents

• Datasheet (PDF)