Solubility: Soluble in DMSO (up to 25 mg/ml) or in Water (up to 45 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Fatty acid synthase inhibitor
Functions
A potent and selective fatty acid synthase (FASN) inhibitor acting via interfering with cofactor binding.
IC50s = 147 and 213 nM respectively for inhibition of acetate and glucose incorporation into total lipids in HepG2 cells. IC50=5.84 μM in an isolated enzyme assay. Displays potent antitumor activity in the MMTV-Neu HER2+ breast cancer model. Reduces HIV-1 virion production by 90% (EC50=213 nM).
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or in Water (up to 45 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
