Solubility: Soluble in DMSO (up to 10 mg/ml with warming).
Storage: -20°C
Stability: ≥ 1 year.
Applications
Ferroptosis inducer
Functions
Ferroptosis inducer. Inhibits the cystine-glutamate antiporter, system Xc- leading to activation of an ER stress response. Inhibition of system Xc- leads to cysteine starvation, glutathione depletion and induction of ferroptosis. Also blocks mitochondrial voltage-dependent anion channels (specifically VDAC2 and 3).
Application Procedures
First dissolved in DMSO (up to 10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
