Enzastaurin, PKC inhibitor

Product Details

Formal Name: 3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione

Alternate Names: LY-317615

Molecular Formula: C₃₂H₂₉N₅O₂

Formula Weight: 515.61

CAS Number: 170364-57-5

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 7 mg/ml with warming)

Storage: -20°C

Stability: ≥ 1 year.

Applications

PKC inhibitor

Functions

Potent and selective PKCβ inhibitor.  IC50 = 6, 39, 83 and 110 nM, for PKCβ, PKCα, PKCγ and PKCε respectively. Induces apoptosis in multiple myeloma cell lines via inhibition of the AKT signaling pathway. Induces mitotic missegregation and preferential cytotoxicity in colorectal cancer cells with chromosomal instability. Attenuates ampheta-mine-stimulated dopamine efflux. Inhibits blood-brain barrier leakiness in a mouse model.

Application Procedures

First dissolved in DMSO (up to 7 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)