EN450, NFkB1 molecular glue

Product Details

Formal Name: N-(2-Chloro-5-(N,N-dimethylsulfamoyl)phenyl)acrylamide

Alternate Names: N-[2-Chloro-5-(dimethylsulfamoyl)phenyl]prop-2-enamide

Molecular Formula: C₁₁H₁₃ClN₂O₃S

Formula Weight: 288.8

CAS Number: 793719-01-4

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to at least 80 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

NFkB1 molecular glue

Functions

Molecular glue that covalently interacts with a cysteine residue on the E2 ubiquitin ligase UBE2D. It displayed anti-proliferative effects in HAP1 leukemia cells. EN450s antiproliferative effects were elicited via proteasome-dependent degradation of nuclear factor kappa B subunit 1(NFkB1).

Application Procedures

First dissolved in DMSO (80 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)