EED-226, PRC2 methyltransferase inhibitor

Product Details

Formal Name: N-(Furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolol[4,3-c)pyrimidine-5-amine

Molecular Formula: C₁₇H₁₅N₅O₃S

Formula Weight: 369.40

CAS Number: 2083627-02-3

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

PRC2 methyltransferase inhibitor

Functions

Potent and selective allosteric inhibitor (IC50 = 23.4 nM) of the EED subunit of the methyltransferase polycomb repressive complex 2 (PRC2). Strongly inhibits proliferation of lymphoma cells with EZH2 mutations and causes shrinkage and slower tumor growth in mice in a subcutaneous xenograft model of Karpas422.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 month.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)