Docetaxel, Microtubule stabilizing agent

Product Details

Alternate Names: Taxotere; RP-56976; NSC-628503

Molecular Formula: C₄₃H₅₃NO₁₄

Formula Weight: 807.90

CAS Number: 114977-28-5

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

Microtubule stabilizing agent

Functions

Antimitotic chemotherapeutic which inhibits via reversible high-affinity binding to microtubules.  Induces apoptosis in a variety of cancer cell lines however, tumor cells can quickly develop resistance to docetaxel via several mechanisms.  Can act in synergy with a variety of other anticancer agents including kinase inhibitors.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)