Solubility: Soluble in DMSO (up to 80 mg/ml) or in Ethanol (up to 80 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
GPR40 antagonist
Functions
A GPR40 receptor antagonist. Suppresses fatty acid-induced elevation of intracellular Ca++. Inhibits palmitic acid potentiated glucose–stimulated insulin secretion in Min6 pancreatic β cells in vitro. Lowers serum insulin levels, increases insulin sensitivity2 in obese Zucker rats (6 mg/kg). Reduces pancreatic β cell apoptosis in obese diabetic (db/db) rats. Protects Min6 β cells from palmitic acid-induced ER stress and apoptosis.
Application Procedures
First dissolved in DMSO (up to 80 mg/ml) or in Ethanol (up to 80 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
