Daunorubicin HCl, DNA damaging agent; anticancer agent

Product Details

Formal Name: 8S-acetyl-10S-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione, monohydrochloride

Alternate Names: Daunomycin; Rubidomycin; RP-13057

Molecular Formula: C₂₇H₃₉NO₁₀·HCl

Formula Weight: 564

CAS Number: 23541-50-6

Purity: >95%

Formulation: Powder

Solubility: Soluble in Water (up to 25 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

DNA damaging agent; anticancer agent

Functions

Antitumor antibiotic used in the treatment of acute myeloid leukemias. Induces DNA damage by intercalation. Induces apoptosis in a variety of cell lines. Inhibition of autophagy with chloroquine enhances daunorubicin-induced apoptosis in K562 cells. Cell permeable.

Application Procedures

First dissolved in Water (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in distilled water may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)