DAPT, g-secretase inhibitor

Product Details

Formal Name: N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester

Alternate Names: LY-374973

Molecular Formula: C₂₃H₂₆F₂N₂O₄

Formula Weight: 432.46

CAS Number: 208255-80-5

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 18 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

g-secretase inhibitor

Functions

Inhibitor of γ-secretase  (IC50 in human primary neurons = 115 nM for total Aβ or 200 nM for Aβ42 specifically).  Oral administration of DAPT has been shown to reduce levels of Aβ in brain extract, cerebrospinal fluid and plasma from mice and rats. DAPT blocks Notch signaling which promotes neuronal differentiation of precur-sor cells. Enhances iPS cells without oncogenes KLF and CMYC. Cell permeable.

Application Procedures

First dissolved in DMSO (up to 18 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)