Formal Name: 1-[(5-(p-Nitrophenyl)furfurylidene)amino]hydantoin sodium salt
Molecular Formula: C14H9N4O5 Na
Formula Weight: 336.23
CAS Number: 14663-23-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 3 mg/ml) or in a 1:1 mixture of DMF and Ethanol (up to 20 mg/ml)
Storage: RT
Stability: ≥ 1 year.
Applications
SR calcium release inhibitor
Functions
Inhibits release of Ca2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor channels with selectivity for RYR1 and RYR3 over RYR2. Protects against quisqualate and NMDA-induced cytotoxicity in cultured cerebral cortical neurons. Displays neuroprotective effects. Prevents cell death in neural progenitor cells derived from Wolfram syndrome iPS cells.
Application Procedures
First dissolved in DMSO (up to 3 mg/ml) or in a 1:1 mixture of DMF and Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO, DMF, or Ethanol may be stored at -20°C for up to 1 month.
