The D/D Solubilizer is a membrane-permeant ligand that solubilizes complexes formed by proteins fused to the self-assembly domain (DmrD), provided in the iDimerize Reverse Dimerization System (Cat. No. 635066).
Features
Brings the disruption of protein complexes under real-time, small-molecule control
Plasmid and lentiviral (Lenti-X) vector formats are available
Previously available from ARIAD as the ARGENT Regulated Secretion/Aggregation Kit
The D/D Solubilizer performs the same function as the AP21998 ligand, which was previously supplied by ARIAD Pharmaceuticals Inc.; however, it is a different molecule than AP21998
Applications
Rapid, reversible changes in the subcellular location, aggregation state, and/or biological activity of engineered proteins in vitro or in vivo Rapid induction of protein secretion Protein trafficking studies Inducible animal models and cell lines
