Cytarabine, DNA damaging agent; antiviral

Product Details

Formal Name: 4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone

Alternate Names: Arabinocytidine; Cytosine β-D-Arabinofuranoside; U-19920A; Ara-C

Molecular Formula: C₉H₁₃N₃O₅

Formula Weight: 243.20

CAS Number: 147-94-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 12 mg/ml), or in Water (up to 24 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

DNA damaging agent; antiviral

Functions

A nucleoside analog that interferes with DNA synthesis and transcription, particularly in tumor cells. Cellular enzymes convert it to its phosphorylated form, Ara-CTP, which disrupts DNA and RNA synthesis when polymerases attempt to incorporate it. For the same reasons, it is also employed as an antiviral. It inhibits proliferation of a variety of leukemic cell lines (IC50s 16-72 nM), but is used primarily against acute myeloid leukemia (AML).

Application Procedures

First dissolved in DMSO (up to 12 mg/ml), or in Water (up to 24 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or water may be stored at -20°C for up to 1 month.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)