Cycloastragenol, Telomerase activator / Senolytic agent

Product Details

Formal Name: 20,24R-Epoxy-9,19-cyclolanostane-3β,6α,16β,25-tetrol

Molecular Formula: C₃₀H₅₀O₅

Formula Weight: 490.7

CAS Number: 84605-18-5

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 15 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Telomerase activator / Senolytic agent

Functions

Cycloastragenol is a novel naturally occurring terpenoid found in Astragalus which was shown to be a telomerase activator. In CD8⁺ T lymphocytes from HIV-infected donors it retarded telomere shortening, increased proliferative potential and enhanced cytokine/chemokine production and antiviral activity. It suppressed lung damage in a idiopathic pulmonary fibrosis mouse model. It has also been shown to be a novel senolytic agent, inducing senescent cell apoptosis and restoring physical function in mice with irradiation-induced aging.

Application Procedures

First dissolved in DMSO (up to 60 mg/ml) or in Ethanol (up to 15 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)