Clemastine fumarate, Histamine H1 receptor antagonist

Product Details

Formal Name: (2R)-2-[2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine fumarate

Alternate Names: Tavist

Molecular Formula: C₂₁H₂₆ClNO·C₄H₄O₄

Formula Weight: 460.0

CAS Number: 14976-57-9

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to 25 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Histamine H1 receptor antagonist

Functions

Histamine H1 antagonist with anti-muscarinic effects at the M1 receptor. Enhances remyelination in a mouse model of demyelination. Displays protective role against neuroinflammation and demyelination via anti-inflammatory and anti-pyroptotic actions. Clemastine promoted oligodendrocyte differentiation in a rat model of spinal cord injury via muscarinic receptor mediated activation of ERK1/2 signaling.

Application Procedures

First dissolved in DMSO (25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)