CL-316243, β3-adrenergic agonist / antiobesity

Product Details

Formal Name: 5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid disodium salt

Molecular Formula: C₂₀H₁₈ClNNa₂O₇

Formula Weight: 465.80

CAS Number: 151126-84-0

Purity: >98%

Formulation: powder

Solubility: Soluble in Water (up to 50 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

β3-adrenergic agonist / antiobesity

Functions

Potent and selective β3 adrenergic receptor agonist (EC50= 3 nM). Displays anti-obesity and anti-diabetic effects in mice. It increases brown fat thermogenesis and metabolic rate and decreases blood insulin and glucose levels. Induces functionally active mitochondrial uncoupling protein (UCP) in white fat. Active in vivo.

Application Procedures

First dissolved in Water (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)