Cedrol (+), Anticancer natural product

Product Details

Formal Name: (1S,2R,5S,7R,8R)-2,6,6,8-Tetramethyltricyclo[5.3.1.01,5]undecan-8-ol

Molecular Formula: C₁₅H₂₆O

Formula Weight: 222.40

CAS Number: 77-53-2

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 10 mg/ml)

Storage: RT

Stability: ≥ 1 year.

Applications

Anticancer natural product

Functions

Cedrol is a sesquiterpene alcohol found in conifers mainly of the genera Cupressus, Juniperus, and Cedrus. It has been found to possess significant anticancer activity against glioblastoma in vitro and in vivo via cell growth inhibition, ROS generation, and DMA damage. Cedrol also displayed synergistic effects with temozolomide against glioblastoma in vitro and in vivo via reduced expression of drug resistance proteins. Cedrol inhibited the growth of human renal adenocarcinoma and amelanotic melanoma cells and induced autophagy and apoptosis in A549 non-small cell lung carcinoma cells.

Application Procedures

First dissolved in DMSO (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)