Capto Butyl hydrophobic interaction chromatography resin

Useful for the intermediate stages of protein purification, Capto Butyl HIC resin combines high capacity, high flow rate, and low back pressure to reduce process cycle times.

• Improved productivity and process economy in downstream operations compared with Butyl Sepharose 4 Fast Flow.
• Very high flow rates and large sample volume processing.
• Excellent chemical stability.
• Resin fulfills industrial demands for security of supply, robust performance, and regulatory support.

Properties of Capto base matrix

Capto resins are based on a very rigid, high-flow agarose base matrix with an optimized pore structure that offers outstanding pressure/flow properties.

Prepacked columns and other formats

Capto Butyl is available in the following formats: 

Process development scale – prepacked

• PreDictor Capto Butyl filter plates – 96-well plates for high-throughput screening or process development.
• PreDictor Capto Butyl RoboColumn units – miniaturized columns for high-throughput process development.
• HiScreen Capto Butyl columns – optimized for method and process development.
• f(x) column, prepacked and precharacterized chromatography column for fast and accurate mechanistic modeling.

Lab/research scale – prepacked for manual purification

HiTrap Capto Butyl columns – for easy use with a syringe, peristaltic pump, or chromatography system.

Lab/research scale – prepacked for automated purification and analysis

HiTrap Capto Butyl columns – for easy use with a syringe, peristaltic pump, or chromatography system.

Process scale purification: prepacked

ReadyToProcess Capto Butyl columns, 1 L and larger columns for clinical manufacturing that minimize the need for cleaning and cleaning validation.

Documents

• Data file (PDF)
• Instructions for use (PDF)