Calphostin C, Protein Kinase C inhibitor

Product Details

Formal Name: Fermentation product from Cladisporium cladosporioides

Alternate Names: UCN-1028C; PKF115-584

Molecular Formula: C₄₄H₃₈O₁₄

Formula Weight: 790.80

CAS Number: 121263-19-2

Purity: >95%

Formulation: powder

Solubility: Soluble in DMSO (10 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Protein Kinase C inhibitor

Functions

A potent and specific inhibitor of protein kinase C (PKC, IC50 = 50 nM). Inhibition of PKC is light dependent and is competitive with the diacylglycerol / phorbol ester binding site. Calphostin C competes with the diacylglycerol / phorbol ester binding site in other proteins such as Munc13-1. Reverses oxycodone-induced tolerance to respiratory depression.

Application Procedures

First dissolved in DMSO (10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)