C-DIM 8, Nur77 Antagonist

Product Details

Formal Name: 1,1-Bis(3′-indolyl)-1-(p-hydroxyphenyl)methane

Alternate Names: DIM-C-pPhOH

Molecular Formula: C₂₃H₁₈N₂O

Formula Weight: 338.40

CAS Number: 151358-47-3

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (35 mg/ml); or Ethanol (35 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Nur77 Antagonist

Functions

An antagonist of the orphan nuclear receptor Nur77 (NR4A1, TR3). Induces reactive oxygen species and ER stress in pancreatic cancer cells. C-DIM 8 mimics the effect of Nur77 knockdown in non-small-cell lung cancer A549 and H460 cells, inhibiting cell growth and inducing apoptosis which was accompanied by decreased expression of survivin and inhibition of mTORC1 signaling. Inhibits the expression of β1- and β3-integrin and blocks integrin-dependent breast cancer cell migration. Decreases expression of the histone methyltransferase G9A (EHMT2) in a variety of cancer cell lines.

Application Procedures

First dissolved in DMSO (35 mg/ml); or Ethanol (35 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)