C-DIM 12, NFkB inhibitor; Nurr1 inhibitor

Product Details

Formal Name: 3,3’-[(4-Chlorophenyl)methylene]bis[1H-indole]

Molecular Formula: C₂₃H₁₇ClN₂

Formula Weight: 356.85

CAS Number: 178946-89-9

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 35 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

NFkB inhibitor; Nurr1 inhibitor

Functions

Activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth. Nurr1 is a suppressor of NFkB-related neuroinflammatory genes in microglia and astrocytes and C-DIM 12 suppresses inflammatory signaling in these cells. Displays neuroprotective activity in a mouse model of progressive neurodegeneration with a strong neuroinflammatory component (50 mg/Kg, oral).

Application Procedures

First dissolved in DMSO (up to 35 mg/ml) or in Ethanol (up to 35 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)