Buparlisib, PI3K inhibitor (pan-Class I)

Product Details

Formal Name: 5-(2,6-Dimorpholin-4-ylpyrimidin-4-yl)-4-(trifluoromethyl)pyridine-2-amine

Alternate Names: NVP-BKM120; BKM-120

Molecular Formula: C₁₈H₂₁F₃N₆O₂

Formula Weight: 410.40

CAS Number: 944396-07-0

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 15 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

PI3K inhibitor (pan-Class I)

Functions

Inhibits Class I PI3K isoforms [e.g. p110α (IC50 = 52 nM), p110δ (IC50 = 116 nM] but not Class III or IV [e.g. Vps34, mTOR, PI4Kβ]. Blocks or pauses glioma cell cycle at G2/M depending on p53 status. At 5 mg/kg, efficiently inhibits phosphorylation of PI3K target AKT Ser473 in mouse brains. Augments chaperone-mediated autophagy (CMA) in lysosomes isolated from mouse liver.

Application Procedures

First dissolved in DMSO (up to 15 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)