A potent and selective HDAC3 inhibitor (IC50 = 289 nM), IC50s for HDAC1, 2 and 6 = 2, 2.2 and >20 µM respectively. Inhibits tumor growth in a mouse xenograft model of human multiple myeloma. Downregulates expression of DNA methyltransferase 1. Increases expression of synaptic proteins in exogenous Aβ-treated cells and mice. Rescues synaptic damage and neuron loss in APP-transfected cells (15 µM) and APP/PS1 mice (30 mg/kg).
Application Procedures
First dissolved in DMSO (45 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
