Bexarotene, Retinoid RXR agonist

Product Details

Formal Name: 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid

Alternate Names: LGD-1069; SR-11247

Molecular Formula: C₂₄H28O₂

Formula Weight: 348.49

CAS Number: 153559-49-0

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 10 mg/ml with warming).

Storage: -20°C

Stability: ≥ 1 year.

Applications

Retinoid RXR agonist

Functions

A highly potent and selective retinoid X receptor (RXR) agonist (EC50=28, 25, 20 nM for RXRα, β, γ respectively). Clinically useful antineoplastic agent for cutaneous T-cell lymphoma Causes complete regression of mammary carcinoma. Bexarotene significantly increases clearance of soluble β-amyloid in a mouse Alzheimer′s model and increases cognitive ability. Reverses apoE4-driven brain pathology and behavioral deficits in vivo.

Application Procedures

First dissolved in DMSO (up to 60 mg/ml) or in Ethanol (up to 10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 week.

Research use only.

Documents

• Datasheet (PDF)